Effect of Different Polymer Concentration on Bio-Adhesion of Antihypertensive Bio-Adhesive Layer

Asian Resonance(P: ISSN No. 0976-8602 RNI No.UPENG/2012/42622 VOL.-IV, ISSUE-II, April-2015 E: ISSN No. 2349-9443)

Abstract


 Aadesh Kumar 

Assistant Professor, Deptt. of Pharmaeutical Sciences, Kumaun University Block Road, Bhimtal Nainital, Uttarakhand


Tanuj Joshi

 Assistant Professor, Deptt. of Pharmaeutical Sciences, Kumaun University Block Road, Bhimtal Nainital, Uttarakhand


Govind Rajpal 

Teaching Personnel, Roorkee College of Pharmacy, Roorkee, Uttarakhand

The term bioadhesion refers to any bond formed between two biological surfaces or a bond between a biological and a synthetic surface. Bio-adhesive system layer will adhere on gastric mucus which can provide significant of gastro-retentive system. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region. Also, longer residence time in the stomach could be advantageous for local action in the upper part of the small intestine, for example treatment of peptic ulcer disease. Furthermore, improved bioavailability is expected for drugs that are absorbed readily upon release in the GI tract Nifedipine- (antihypertensive drug) which is primarily absorbed from stomach and required more than three times a day but by using bio-adhesive layer it can be retain on stomach for more absorption and will reduce the frequency of dosing. The aim of study was to formulate and optimize the bio-adhesive gastro-retentive system of anti-hypertensive drug Nifidipine and To study the effect of different polymer concentration on Bioadhesion.

for full paper please visit below link :

http://www.socialresearchfoundation.com/upoadreserchpapers/1/44/1510080715191st%20adesh%20kumar.pdf


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