Effect of Splenectomy on Testicular Activities in Immature Male Albino Rats

Asian Resonance(P: ISSN No. 0976 - 8602 RNI No.UPENG/2012/42622 VOL.-IV, ISSUE-III, July-2015 E: ISSN No. 2349 - 9443)

Abstract


 Madhumita Debnath 

Assistant Professor, Deptt. of Physiology, Dr. K.L. Bhattacharyya College, Ramrajatala, West Bengal


Moulik Debnath 

Assistant Professor, Deptt. of Anatomy, Murshidabad Medical College & Hospital, Berhampore, West Bengal

Immune system in mammals has intimate relationship with reproductive system. Steroids in both sexes have been shown to influence activities of primary and secondary lymphoid organs. Various immune effector cells and molecules too, on the contrary, modulate functional activities of sex organ. This present study has been designed to explore the functional relationship between male reproductive system and immunity. The specific objective is to study the influence of a major lymphoid organ (spleen) on male gonads in immature system of rats. The study was conducted on 12 immature male albino rats of Wister Strain. Animals were divided into two groups. One group was subjected to splenectomy and the other was considered as control, not being exposed to splenectomy. Both groups of animals were kept for a period of 56 days in aseptic laboratory conditions. The animals were sacrificed and tissues were collected to perform biochemical and histometric assay. It was found that testicular ∆5 , 3β-HSD and 17β-HSD activities were marginally reduced in splenectomised group. Plasma testosterone level decreased significantly in splenectomised group in comparison to control. Histometric studies indicated that seminiferous tubular diameter and epididymal sperm count were also reduced in splenectomised group. Activities of two important anti-oxidant enzymes- catalase and peroxidase were found to decrease in experimental group in comparison to control. Estimation of lipid peroxidation from quantification of TBARS and CD was performed in both groups which showed that there was increase in the level of these products of free radicals in splenectomised group. Overall the study showed an inhibition of testicular activities in male albino rats following splenectomy.

for full paper please visit below link :

http://www.socialresearchfoundation.com/upoadreserchpapers/1/61/1510151232251st%20madhumita%20debnath.pdf


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